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Radak Z, Zhao Z, Goto S, Koltai E (2011) Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

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This results from G3P accumulation upstream and shunting of hexose monophosphates to the oxidative phase of the PPP to generate nicotinamide adenine dinucleotide phosphate (NADPH), which in turn fuels antioxidant systems

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Thus, as shown in Figure 16 , the (probably not surprising) conclusion is that niclosamide can readily revert to its most stable solid forms (--the monohydrates and similar cosolvates identified by van Tonder et al (2, 62)) that have a lower solubility of niclosamide in aqueous solution when in contact with these solid forms